????:1???????:?????????????

2???????

3????????92??95

4?2022?????????

5???????

????????11???10????(?????????????????? ?)????????????????????113??;???????14.1???????????????????????????;?:????????????????;????????????????????????FDA????;???;??????????????????KRAS G12C???????????????;?;??????……?????????????????????????????????????????11????????4?????????-11?10????????????,?????????????

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11??????????????????5??????????????,????,????,????“?”?????????????????????????“????????????????”????,??????????,??????????????????????,??????????????

?:????????113???????????

11??????7??,??????????????,???40????????????????,????“????????????????????????”???????30??,?,113?????????«?????????(ICD-11)»?,?????????????,??????,??ISO/TC249,????????????113????????

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11?7??????????,??????App?????????????,???????????????????,??????????????,??2.1??????????14.1??,??????571%??2022?4????,????????????,???????????????????????????????????????????????(???????????????????????????)??????????,?(600436)?????????????

??????????????????????:??????

11??????????????????8??????,???????,??????????????????????????????????????????????????HRS-2189???????????????????????????HRS-5041 ????????????????HRS-1358???HRS-8080?????SHR-8068??????????????????HRS-620 ????????????«?????????????»,?????????

?????????FDA????????????????

11?8?????????????,????,????(FDA)???(New Drug Application,NDA),?????????????????,?????????????? FDA ??,?????(EGFR)20 ??????????????????(Exon20ins)???(NSCLC)????????????? FDA ?????

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11??????????6??,?,????????®(????????????)?,????????????????????????(ANCA)??????????????(???????????????????[GPA]?[MPA])???????????

???????????????KRAS G12C??????????

11?9???????????,????,?KRAS G12C?????(????????????????????????“?????????????????????????????????”)??????????????????????????,??KRAS G12C?????(NSCLC)?????????,???????????????????,????1????????????????????????,?5?,??????????6???KRAS G12C?,????KRAS G12C?????????????????????????

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11??????7?,????????????«???????????????????????????»?«??????????????????»???,?,???????????????????????????????,??????????????????????«????»«????????»????,???????????,??????????,?????????,??????,???

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???????????Aradhana Sarin???????????,???,?,??

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