“???????????????????????????????”“??????????????????????????????????????”“?,?????”????????,???????,????????,?????,????“?????????????????”??,?????????????????????????????“?????”????????(AD),??,??,??????????????AD????????1,000??????,?,??2050??????,???AD????????????4,000?????????,??

2024?????????????7??????????20????-21??????????????,????,??????????????“2024??????”??????????????????“2024????:????????????????????????????????????????????????????”,????????,?????,???????

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???????????????????(ADI)????????????????????«??????????????????????????????????2018?????»?????,????????????????????3???????,?????????,????60%-70%??????AD????????????????????????,AD??,??????????????????

???(MRI)???? ????????????(????)???

AD????60???????,????????,????,????????AD????????“?????”?????????????(NIA-AA)??????????AD?“AD??????(AD continuum)”,????AD?????????10-20???,AD???????,??

????,????,?????????????????????????????????????????????,??????????????????AD???????????,????AD?????????

?????AD??????,??,?????????????????????AD?,???E(APOE)???e4????????AD????2022??????????,????????«???????2021»???????????????:APOE e4???????????AD?,???AD?????4-10?????????,?????????????????50%??AD????APOE e4????????

???????2023??????????????12????????????????,?3487428??APOE ?????????,???????????????????APOE e4???????????615592,?17.65%?????????????????,??????????APOE e4e4???23949(?????0.69%),??????????APOE e3e4?????????????????534783(????????15.33%),???????????????APOE e2e4?????????????????56860(????1.63%)?

2023????,????«JAMA Neurology»???????????:???,???APOE e4e4???????????AD?????????????26.13????;????APOE e3e4???????AD????????????4.54??????;???????APOE e2e4?????AD??2.96????????????????,APOE ???????AD?????

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???????2023??????????????12????????????????,?3487428??APOE ?????????,???????????????????APOE e4???????????615592,?17.65%?????????????????,??????????APOE e4e4???23949(?????0.69%),??????????APOE e3e4?????????????????534783(????????15.33%),???????????????APOE e2e4?????????????????56860(????1.63%)?

2023????,????«JAMA Neurology»???????????:???,???APOE e4e4???????????AD?????????????26.13????;????APOE e3e4???????AD????????????4.54??????;???????APOE e2e4?????AD??2.96????????????????,APOE ???????AD?????

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???,????AD?????????????“??”,?????????????????????????????????????????,????AD????????90%,???????12.9%,??????????????AD?????????????????,????,?““?????????”??“???????????”??”???AD?,??58????170??????,?????????????????????????????????,??AD????????,??????????????????

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