??????“??” ?????

????:??????:??????

????????????????

??,??????????2????,??????????????????????,?????????/???“????”??????????????,???????

??????????,????????????????,?????????????????????“???????????”??????????????????,???????

1.????????????

????-1(GLP-1),???????????,????????????????????????????????GLP-1?????????,??????-4(??)??????????,?????2?????????????,???????,???

????????????GLP-1???????,????????GLP-1????????,??7???????,???????????????????,?????

??,????????GLP-1????????????,?,?????????????????????????????????????????????????,????????,????????,???????

??,??2021??,???????????????????????6?????????????25?????/????

???????:???????(BMI)??????30??????????;???????27-30??????,?(????????????????????????????)????????????????,?????27?????????????,???????????,????????,????????????????????

?????????,?????????????????????GLP-1????????????,?????,???????,???????????,???????????????,???4.5mmol/L????????,GLP-1?????????,????

??,??????????????????????????????????????????????????????????????????????????????????????,?????,????????,????,???????,????????????????????

??????:??????????2???,?????????????????,????????????????????????????,???18?????????

2.“???????????????”???????“??????”?

?????“???????????”,????????????????“?????????”,?????

??“??????????????”,??????????“??”,???,??GLP-1????????,??

“???”?????????????????2mg?4mg??,????0.25mg?????,??;4??0.5mg,??????;??0.5mg?????????4?????????????????????,???????????1mg,???????????1mg?

“????????????? ????????????????”?????? ????0.25mg?0.5mg?1mg?1.7mg?2.4mg????,????????,??????????0.25mg????????????,????????????????4??,????????????2.4mg???????????????“?”??????????“?”?

??????????????,??????“??????”???????????,??????,????????????;“????????????????????????”???????????,?????????????????

??????????????????,“??????????????”??????????????????,???????,?????“???”??,????????

?????????????????,?????“??”?,??“???”????????,??????????????,??,??????,??????

3.??

?????????,????????,????????2010???????????,???????,???????,??????????,????????????????????????????,??????????????2014??????????,??????GLP-1?????2023?????7???,??????????????

????,??????????????????7?????????,???????,?????????????????????13???????????,??????????????,?????,???????,????????????,???“???????????”?

?????????,??????,????????????,????????????????????????,????

???,???????,????????????,???????,???????????????????????,??????????,??,????????;????????,??

4.??????????????????

?,?????????????????????????????????????1997?????????,???????????

??,?????????,??,????????????????????????2????????????????,??????????“????”?

??,?,?????????????,???,???,???????????????,??????????????,1997????“?????”???,??,??????2010??????????

????????2017????????12??????????,2021??????????????6?????????,??????????????????????????“?????????????”?????????7????,??“????????????????????????”?????3??????????????????????????,???,????

??,?????????,????????????????:???,???????????????????????,????,?????????,????????????

??,??????????????????,??????????,??????????????????“????????????????”,???????????????????????,????????????,???????????????????????,???;???????????,????????????????????????????,???;?,?????????????;??????,??????????????????(??????10????20???),??,?????????,??????????????????

?????????????????????????,??30?????????,????????2????????????30??????????????????????????????????????????????????????,??????????

?????,????????,????????????,??????????????????????(BMI=32.5)?????????,???

??,???????????“?????????????????????”,????????????,???????

(???????????)

(??) ???:??????????????????