“?????????????????????”“????????????????????????”“?????,????”????????????????????,?,???,?????????,???????????“??”??????????????????,???????????????“????”????????(AD),???,??????????????,?????AD?1,000???????,????,??????2050?????????????,?AD????????????????????4,000???????????????,??

2024????????7????20?????????????????-21???,?????????????????,????????????????????????????????“2024?”?????????????????“2024????:?????????????????????????????????”,????,?,???

???????,???????AD??????,??????????????AD“???????????????????????????????????”??????????????,??????“??”???????,??????????????

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??????????????AD???????? ???????AD????“???????????”

??,????????????????????,???,?????????????????????7??20???????????,????“2024?????”?,??????????“?????,????????”????????

??????????????????,??????????????????????????????????????????????Quanterix?????,??????????????“????????????????????????????????????????”,?????????????,???????

“??????????????”?????????

?,???????:“??,???????,????????,?????,????,???????????????????????????????????,??,???????????,???????????????????????????????????”

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?????????AD??????????????????“???” ????????????????????

????????“??????”,???,??????????????????????????,??,?????,????????????????????????“??”?????????????,???,????AD?,?????,?????

????????????(ADI)????????«??2018???????»????,??????????????????3??????????????,??,??60%-70%??????AD?????????????,AD?,?????

??????????(MRI)????????? ??(?????)?????

AD??????????60?????,????,????,?????????????AD?????????“????”??????????????????????????????????(NIA-AA)????AD????????????“AD?????(AD continuum)”,?????AD?????10-20?????????????,AD??????????,???????????????????????????????????

???????????????????,?,???????????????,???????AD?,?AD?????

???????AD???????,??????,??AD??????,????????????E(APOE)????e4???????AD?????????????????2022?????????,?«??2021»?:APOE e4??AD????,??????????AD??4-10???,????????50%????????AD?????????????????APOE e4?????

?2023??????????????????????12?????????????????????????????,????3487428?????????APOE ??,?????????APOE e4??????????????????????????615592,???17.65%?????????????????????????,?????APOE e4e4?????????23949(???????0.69%),??????????????APOE e3e4???????????????????????534783(?????15.33%),???????APOE e2e4????56860(??1.63%)?

2023??????????????,????«JAMA Neurology»???????????????????:????,????????????????APOE e4e4???AD????26.13??;?????APOE e3e4???AD????????????????4.54??;???APOE e2e4??AD???????????????2.96?????????????????,APOE ?????AD????

«2024????60?» ????APOE?

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?????????????????,???AD????“????”,?????????????????????????????????????????,???????????AD?????????????????90%,???????????????????????12.9%,?AD??????????????????,??????????????,????““??????????????”????????“?????”???????????????????”???AD???,?58????????170?????????,????????????????,???????????AD????????,??

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??????????(MRI)????????? ??(?????)?????

AD??????????60?????,????,????,?????????????AD?????????“????”??????????????????????????????????(NIA-AA)????AD????????????“AD?????(AD continuum)”,?????AD?????10-20?????????????,AD??????????,???????????????????????????????????

???????????????????,?,???????????????,???????AD?,?AD?????

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?2023??????????????????????12?????????????????????????????,????3487428?????????APOE ??,?????????APOE e4??????????????????????????615592,???17.65%?????????????????????????,?????APOE e4e4?????????23949(???????0.69%),??????????????APOE e3e4???????????????????????534783(?????15.33%),???????APOE e2e4????56860(??1.63%)?

2023??????????????,????«JAMA Neurology»???????????????????:????,????????????????APOE e4e4???AD????26.13??;?????APOE e3e4???AD????????????????4.54??;???APOE e2e4??AD???????????????2.96?????????????????,APOE ?????AD????

«2024????60?» ????APOE?

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?????????????????,???AD????“????”,?????????????????????????????????????????,???????????AD?????????????????90%,???????????????????????12.9%,?AD??????????????????,??????????????,????““??????????????”????????“?????”???????????????????”???AD???,?58????????170?????????,????????????????,???????????AD????????,??

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