??????????????

????:????soul????:??????

????????????2025?2?21???,??«??????????????????»?“Base-modified nucleotides mediate immune signaling in bacteria(??)”???????(??)???????,????????????“?”(Kongming),??“???”??,?????

????,???????????????????????????????????????????????,??????“?????”?????????????????????1950?????????(?????????????????cAMP?cGMP)???????????,??????????????????????,?????????????????????,????,??,?KomA(??????????A)?KomB(????????????????????B)?KomC(??C)???????????????,?????????????????(DNK)?????????????“????”:KomA???????DNK??????,??(dAMP)?????????dITP????KomC?????????????????????NAD⁺,??“??????”??????,?????????????,???????“?????????????????”??????????,????“??????”???????,?????

?,“??????”?????????????????????????????????????,???????????(????????????KomB-KomC??????????KomA)?????????????????????,???????????dITP??????????????????:???????????????????????,??(??????ADA?????????????)????,?????

(???? ???? ??????) ??????:??????????