????:1?????????200?:??????????

2???????????

3?????wx

4???????150???

5????????????

????2025???????2?21????,???«??????»??“Base-modified nucleotides mediate immune signaling in bacteria(????)”?????????????????????????(???)??,????????????“??????????”(Kongming),????????????“?????”?,????????????

?????????????????????,????????????????,??????“??????”????????1950?????????????????(?cAMP?cGMP)?,????????????????????????????????????????,???????,?????????,???????????????????????,??KomA(???????A)?KomB(??????B)?KomC(??C)????????,?????????????????(DNK)??????“?????????”:KomA??????DNK??,????????????????(dAMP)??dITP??????????KomC?????????????NAD⁺,?????????????“???”?????????????????,??,????“????????????????????????????”????,?“??”??,???

??,“???????????????”????,????????????????????(??????????????????KomB-KomC????????????KomA)??????????????????????,??????????????????dITP????:?????????????????,??????(??????????????????ADA???????????)?????????,????

(?????????? ???? ?) ?????????????????????:?????