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???????????2025??????????????????2??21????????????????,????????????«??»??????????“Base-modified nucleotides mediate immune signaling in bacteria(??????)”??????(????)??????????????????,????????????????????“?????????????”(Kongming),??????????????????“??????”???,??
?,??????,???“???????????”??1950????(??????????????????cAMP?cGMP)?????????????????????,??????????,??????????,?????????????,????,??KomA(????A)?KomB(?B)?KomC(??C)?????????????,????(DNK)?“???????????????????????”:KomA???DNK????,?????(dAMP)??dITP??????????KomC????????????NAD⁺,??“????????????”????????????????,????,??“???????”??,?????????????????“??????”???????,??????????????????
??????,“?????????”????????????????????,??????????(??KomB-KomC???KomA)??????????????????????????????????????????????????????????????????,??dITP?????????????:??????,??(?????????????ADA???????????????)???????,?????
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