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????????????????????????????2025????2?21?,????«???»?????“Base-modified nucleotides mediate immune signaling in bacteria(?????????????????????)”???????????????????????????(????????????????????)??,?“?????????????????????????????????????”(Kongming),????“???????????????????????”??,???

??,???????????????????????????,?“???”???1950???????(??cAMP?cGMP)??????,????????????????,???????,???????????????,??,?????????????KomA(??????????????????A)?KomB(??????????????????B)?KomC(???????????C)????????????????,??(DNK)??????“???????????”:KomA??DNK??,??(dAMP)?????????dITP???????????????????KomC????NAD⁺,?????????????????“?????????????????”??????????????????,??????????????????,????“????????????”???????????????,?“??”???????????,???????

??????,“????”??????????,????(????KomB-KomC??????KomA)???????????????????????,??????dITP???:???????,????(???ADA??)?????????????,?????????????

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