?? ????????????20.2% ???????????????13.7%
????:1???????:??????
2???????
3???????????
4?????????
5?????????????
???????????????????????12?????????5??? ????????????????,??????????????3b??????SURMOUNT-5?topline?????,????(tirzepatide)????????(semaglutide)?,????????????????????????????????1.47??????????????
??????????????,?????????????20.2%,????????????????13.7%i??72??????????,??,???????????5??????????,????????????
??, ????????,??????GIP??GLP-1????????????????GIP????????????GLP-1???????????????????????????????????????????(CKD)????????????????????????????(MMO)????????????????,???????????????????(FDA)????????????????????(OSA)???????????????????(FDA)???????????????????????(HFpEF)??????????????????
???????????????????????????2022?????????????????5????????????????????13??????????????(FDA)??????,?????????????????????2??;2023?11????8???,FDA??????????????????????(BMI=30kg/m2)??????(BMI=27kg/m2)???
???????GIP(???????????????)????????GLP-1(????-1)???????,?????????????????????????
“??,??,???,”??????Leonard C. Glass??????,“?????,???????,????????????????????????,???????????????1.47??????????FDA?GIP/GLP-1?????,??????????”
???:“?????????????????,??????,???????????????????????????”
???????,?????????????????????????????,???31.6%??25%,?????16.1%?????
???????????????SURMOUNT-5?????,???????????SURMOUNT???????????????????????????,??
?????????SURMOUNT-5???,??????????????????????
????,SURMOUNT-5(NCT05822830) ????????????????????????????????????????3b ?????,????(?????????????????????????????????????????????????????????????)?????????????????,??(tirzepatide)?????????????????(semaglutide)???????????????751???????????????????????,?????????1:1????,?????????(10mg??????????????????????????????????15mg)???(1.7mg?????????????????????????2.4mg)???????????????72????????????,????????????
i????????????(treatment-regimen estimand)???,?,???????????????(????????)???????,?,??? ??????:?????????????????????