???????????????????????12?????????5??? ????????????????,??????????????3b??????SURMOUNT-5?topline?????,????(tirzepatide)????????(semaglutide)?,????????????????????????????????1.47??????????????

??????????????,?????????????20.2%,????????????????13.7%i??72??????????,??,???????????5??????????,????????????

??, ????????,??????GIP??GLP-1????????????????GIP????????????GLP-1???????????????????????????????????????????(CKD)????????????????????????????(MMO)????????????????,???????????????????(FDA)????????????????????(OSA)???????????????????(FDA)???????????????????????(HFpEF)??????????????????

???????????????????????????2022?????????????????5????????????????????13??????????????(FDA)??????,?????????????????????2??;2023?11????8???,FDA??????????????????????(BMI=30kg/m2)??????(BMI=27kg/m2)???

???????GIP(???????????????)????????GLP-1(????-1)???????,?????????????????????????

“??,??,???,”??????Leonard C. Glass??????,“?????,???????,????????????????????????,???????????????1.47??????????FDA?GIP/GLP-1?????,??????????”

???:“?????????????????,??????,???????????????????????????”

???????,?????????????????????????????,???31.6%??25%,?????16.1%?????

???????????????SURMOUNT-5?????,???????????SURMOUNT???????????????????????????,??

?????????SURMOUNT-5???,??????????????????????

????,SURMOUNT-5(NCT05822830) ????????????????????????????????????????3b ?????,????(?????????????????????????????????????????????????????????????)?????????????????,??(tirzepatide)?????????????????(semaglutide)???????????????751???????????????????????,?????????1:1????,?????????(10mg??????????????????????????????????15mg)???(1.7mg?????????????????????????2.4mg)???????????????72????????????,????????????

i????????????(treatment-regimen estimand)???,?,???????????????(????????)???????,?,??? ??????:????????????????????? “??????”_????

?? ????????????20.2% ???????????????13.7%

????:1???????:??????

2???????

3???????????

4?????????

5?????????????

???????????????????????12?????????5??? ????????????????,??????????????3b??????SURMOUNT-5?topline?????,????(tirzepatide)????????(semaglutide)?,????????????????????????????????1.47??????????????

??????????????,?????????????20.2%,????????????????13.7%i??72??????????,??,???????????5??????????,????????????

??, ????????,??????GIP??GLP-1????????????????GIP????????????GLP-1???????????????????????????????????????????(CKD)????????????????????????????(MMO)????????????????,???????????????????(FDA)????????????????????(OSA)???????????????????(FDA)???????????????????????(HFpEF)??????????????????

???????????????????????????2022?????????????????5????????????????????13??????????????(FDA)??????,?????????????????????2??;2023?11????8???,FDA??????????????????????(BMI=30kg/m2)??????(BMI=27kg/m2)???

???????GIP(???????????????)????????GLP-1(????-1)???????,?????????????????????????

“??,??,???,”??????Leonard C. Glass??????,“?????,???????,????????????????????????,???????????????1.47??????????FDA?GIP/GLP-1?????,??????????”

???:“?????????????????,??????,???????????????????????????”

???????,?????????????????????????????,???31.6%??25%,?????16.1%?????

???????????????SURMOUNT-5?????,???????????SURMOUNT???????????????????????????,??

?????????SURMOUNT-5???,??????????????????????

????,SURMOUNT-5(NCT05822830) ????????????????????????????????????????3b ?????,????(?????????????????????????????????????????????????????????????)?????????????????,??(tirzepatide)?????????????????(semaglutide)???????????????751???????????????????????,?????????1:1????,?????????(10mg??????????????????????????????????15mg)???(1.7mg?????????????????????????2.4mg)???????????????72????????????,????????????

i????????????(treatment-regimen estimand)???,?,???????????????(????????)???????,?,??? ??????:?????????????????????