???????????2025?????????????????????????????????????2????????????????????????????21??????,??????????????????«?»??“Base-modified nucleotides mediate immune signaling in bacteria(????)”????????(????)????????????????????,??????“????????????”(Kongming),???????????????????????“????????????????????”??,??????????????

????,????????????,?????????????????“??????????”?????1950?????????(???????????????cAMP?cGMP)?????????????,?????????????,????????,????????,????????????,??KomA(??????A)?KomB(??B)?KomC(????C)??????????????????????,?(DNK)???????????“???”:KomA??????DNK???,????????????????(dAMP)??dITP??????????KomC??????????????????NAD⁺,????“??”?????????????????????,??,?????????????????“?????????????????????”??????,???“??”???,??

???,“??”?????,????(?KomB-KomC????????????KomA)?????????????????????,???????dITP???????????:??????,?????????(??????????ADA???????)????,??

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