?? ???????????????20.2% ????????????13.7%
????:1???????:2021?????????
2??????????
3???????????
4???????200
5?????????
?????12?????5???????????????????????? ???????????????????????,???????????????????????3b??????????????????SURMOUNT-5?????????topline??????????????,??????????????????????????????????(tirzepatide)??(semaglutide)?,????????1.47??????????
???,??????20.2%,?13.7%i?????????????72??????,??????,????????5??????,???
?????????????, ??????????????????,???GIP??????GLP-1???GIP?????GLP-1???????????????????????????????(CKD)????????????????(MMO)????????????????,??(FDA)???????????????(OSA)?????????????????????????????(FDA)??????????????(HFpEF)?????????????????????????????
??????2022??????????5?13?????????(FDA)??????????????????,???2??????????;2023????11????????????????????8???,FDA???????(BMI=30kg/m2)??????????????(BMI=27kg/m2)?????????????
?????????????????GIP(????????)?????????????GLP-1(??????????????????????-1)????????????????????,??????????????
“????????????,???????????????,????,”?????Leonard C. Glass??,“?????,?????,?????,???????????1.47???????????????????????????????????????FDA???GIP/GLP-1???????,??????????”
???????????????:“????,?????????????????????????????,????????????????????????????????????????????????????”
??,?????????????????,????????????31.6%????25%,???16.1%????????????????????????
????????????????SURMOUNT-5???????????,????SURMOUNT??????????????????????,?????????????????????????????????
?????????????????SURMOUNT-5???,???????
??????????,SURMOUNT-5(NCT05822830) ????????????????3b ??????????????,??(?????????????????????????????????????????????????????????)???????????,?????????????????????????(tirzepatide)????????????(semaglutide)?????????751???????????????,????1:1???????????????????,???????(10mg?????15mg)???(1.7mg?2.4mg)?????????72??????,??
i???????????????(treatment-regimen estimand)???????,??,?(??????????)??,??????,?????????????????????? ??????????:????????????