?????12?????5???????????????????????? ???????????????????????,???????????????????????3b??????????????????SURMOUNT-5?????????topline??????????????,??????????????????????????????????(tirzepatide)??(semaglutide)?,????????1.47??????????

???,??????20.2%,?13.7%i?????????????72??????,??????,????????5??????,???

?????????????, ??????????????????,???GIP??????GLP-1???GIP?????GLP-1???????????????????????????????(CKD)????????????????(MMO)????????????????,??(FDA)???????????????(OSA)?????????????????????????????(FDA)??????????????(HFpEF)?????????????????????????????

??????2022??????????5?13?????????(FDA)??????????????????,???2??????????;2023????11????????????????????8???,FDA???????(BMI=30kg/m2)??????????????(BMI=27kg/m2)?????????????

?????????????????GIP(????????)?????????????GLP-1(??????????????????????-1)????????????????????,??????????????

“????????????,???????????????,????,”?????Leonard C. Glass??,“?????,?????,?????,???????????1.47???????????????????????????????????????FDA???GIP/GLP-1???????,??????????”

???????????????:“????,?????????????????????????????,????????????????????????????????????????????????????”

??,?????????????????,????????????31.6%????25%,???16.1%????????????????????????

????????????????SURMOUNT-5???????????,????SURMOUNT??????????????????????,?????????????????????????????????

?????????????????SURMOUNT-5???,???????

??????????,SURMOUNT-5(NCT05822830) ????????????????3b ??????????????,??(?????????????????????????????????????????????????????????)???????????,?????????????????????????(tirzepatide)????????????(semaglutide)?????????751???????????????,????1:1???????????????????,???????(10mg?????15mg)???(1.7mg?2.4mg)?????????72??????,??

i???????????????(treatment-regimen estimand)???????,??,?(??????????)??,??????,?????????????????????? ??????????:???????????? “??????”_????

?? ???????????????20.2% ????????????13.7%

????:1???????:2021?????????

2??????????

3???????????

4???????200

5?????????

?????12?????5???????????????????????? ???????????????????????,???????????????????????3b??????????????????SURMOUNT-5?????????topline??????????????,??????????????????????????????????(tirzepatide)??(semaglutide)?,????????1.47??????????

???,??????20.2%,?13.7%i?????????????72??????,??????,????????5??????,???

?????????????, ??????????????????,???GIP??????GLP-1???GIP?????GLP-1???????????????????????????????(CKD)????????????????(MMO)????????????????,??(FDA)???????????????(OSA)?????????????????????????????(FDA)??????????????(HFpEF)?????????????????????????????

??????2022??????????5?13?????????(FDA)??????????????????,???2??????????;2023????11????????????????????8???,FDA???????(BMI=30kg/m2)??????????????(BMI=27kg/m2)?????????????

?????????????????GIP(????????)?????????????GLP-1(??????????????????????-1)????????????????????,??????????????

“????????????,???????????????,????,”?????Leonard C. Glass??,“?????,?????,?????,???????????1.47???????????????????????????????????????FDA???GIP/GLP-1???????,??????????”

???????????????:“????,?????????????????????????????,????????????????????????????????????????????????????”

??,?????????????????,????????????31.6%????25%,???16.1%????????????????????????

????????????????SURMOUNT-5???????????,????SURMOUNT??????????????????????,?????????????????????????????????

?????????????????SURMOUNT-5???,???????

??????????,SURMOUNT-5(NCT05822830) ????????????????3b ??????????????,??(?????????????????????????????????????????????????????????)???????????,?????????????????????????(tirzepatide)????????????(semaglutide)?????????751???????????????,????1:1???????????????????,???????(10mg?????15mg)???(1.7mg?2.4mg)?????????72??????,??

i???????????????(treatment-regimen estimand)???????,??,?(??????????)??,??????,?????????????????????? ??????????:????????????