?? ??????????????
????:1?????szsn:400??3????
2????????
3???????
4?????????
5??????100????
?????????? (?)12????8?,????????,??????????????????????,?,?????????????,????????,????????????????
??????,????,?????????????????????????????????????????,????,?(AFP)??,?????19(CYFRA21-1)???,??????????(CEA)??????
??,????????,???????,???????????“???”???????????,????????
?,?,??????????????????????????10????????????????????????,????????
?,????,???????????????,????????????50?,??????????,??,???10%?
?????????????,???????,????,???????,?,???,???????
?????????12????????????????2??,????????????????????17??,??????????????11?30????????,???????,????????????????????????,????????(ProGRP)???????149??/??????,??40??????????????????????????????/???????,???????????????????,???50?,???????????,?,????,????????????????,???????,???????
“??????,????????????,??????”????????????????,??,?????????,???????????????????????,?????????????????
??????? 1
?????“??”
?????“????????????????????”,??????????????,??“???????”,????,??????????????
????,??????(????????????????CA125??????????CA19-9??????????????PSA)??????,????????,????500??????????220???,??127?????50???????,????????????,??????????“?????????????????????”?
??,???????????????????,??????????????,??????“???????????”?
?????????? 2
?????????????
??,???????????????????,???????,???????
???????????,??????,?????????????????????19???CT?????,???????????????????????????????????,??“?????”??,??108?50???,??????????19???????????????155???????????????50?,?163????????
? 3
??????????
???????????????????,??“?????????????”????????????,?????????,?????????
?1-3?????,??????????(TPSA)??????????????(FPSA)???????????,?????????960?,?????????????????2880?,?????????????,???????,????400?????????,????????1680????,????????????????
¦ ?????
??91?????????????26?????
??,2024?????????????????????,???????????????,?????????????????91??26???????,?????????,????
?????????ADC?PD-1/PD-L1???????????PD-1/VEGFA?????,????????????????????????HR?????????/HER2????????????????
???????“ADC????????????????”?“??????????????????????????????????????????????”????????????????????????????????????????????,????2024?????????6?20???????,????100mg/??????????8860?6912?????????????,???????????22%???????,55kg?????????????????????3????????????????,??????6000??????????,??????????????????10?????
??????????????????,?????,???????,????????????,?40????????????????14.9%,?????????????35?6.5%;??2%,????????????
??,????????????????????????????????????,??50???????????,???????????????13220?/125mg/??????6166?????????/125mg/???????????,????53.4%;“???????????”?????????????? ??????????:???????????????