???????????????

??

?????????1????14?? (????????????? ??????)“?????,?????????????????,??????????????”?14????,“?????????????(ADC)?????,????????????????,??????????,???????”

?,???????,????????????????,???????????,????,“????????????????????”???

??????,???????????,???????,??:??????????????????????????????,?????????,???????20%???????????30%???????????????,????:????“??????????????,??????????????”??,?????????????,????

???,???????????,??:????????????????????,?????????????,??????????????,??????????????????????????????????????????????????????,????????????,????????,???,??????????,?,??????,????????

????,??-2(HER2)????????????,??????????????“HER2?”??????“HER2?????????”????????,???????HER2??????????,???HER2??,HER2???

??,?,HER2??????20%??????????,?,????????????????????????????,ADC???“HER2????????HER2??????????,???????ADC?????????????,????,????????????????HER2??????,ADC??????,??????????????‘1+1>2’?,???”

HER2????????45%??????????55%???????,????????????????HER2?,???HER2??????,??????????HER2??????????????????????:“??????HER2???????????????????,????ADC????HER2??????????????HER2????????????,?????????????????,???????????????HER2???????????,?????????,???????????”

?,ADC?????????????????,?????????????????,ADC?????????????????;??????????????????

??????????,???2017????????????????,???????,?,???????????,???????????????????????????????????????:“????,??????,????????”

??????????????,???????????????,????,??????,??,??????????????????:??????????????????????????????????????????????????????,??????,???????????????40?????????????????B?????,?????????????????????????????????,?????????????:??????????????????????????40??,?????????????????????????,??????(??) ???????????????:???

?????????

?????????????????????????

????????