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????:?????????:????????2019

??2025?????????????????????????????????????2??21???????????????,?«??????????»??“Base-modified nucleotides mediate immune signaling in bacteria(????)”???????????????????????????(?????????????)?????,?“????”(Kongming),??“??????????????????”???????????,??????????????????????

??????,????????????????????????,???“?????????????????”?????????????????????????????1950?????????????(???cAMP?cGMP)??????,???????????,????????????????,?????????,??,???????????KomA(??????A)?KomB(??????????????????B)?KomC(??????????????????C)??????????????,????(DNK)????????????“??”:KomA??DNK???,???(dAMP)????dITP????????????????????????KomC????NAD⁺,?????????“??????”???????????????,????,?????????“???????”?????,????“?”???????????????????,?????????????????????

??????????,“?????????”???????,?(??????KomB-KomC????????????????KomA)?????????????????????,???????????dITP??:??,?(?????????????????ADA??)?,????

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