????:1???????:??95??

2????????95?98??

3?????

4??????????

5?????2021???????

????????1???????????????14?? (? ????????????)“?????????????,??,???????”????14?????????????,“???????(ADC)???????,??????,?????????????????,?????????”

?????????,?????????,??????????????????????????????,????????????????????,??????????,“??????”???????

??????,???????????????,??,??????????:??????????????????????????????????,??????????,????????????????20%????30%?,??????:??????????????????“???????????????,???????”??????????????,??????????,?????

?????,??,???????????????????:??????,?????????,?????,?????????????????????????????????????????????????,?????????????,?????,?,??????????,?,??????????,???

??,???????-2(HER2)???????????,???????????“HER2?????”?????????“HER2??????”????????????????????,?????????????????HER2????,?????HER2??,HER2?????????????

????????,???,HER2?????????????20%?????,??,??????????????????????????????????????????,ADC??????????????“HER2??????HER2??,??????????????ADC???????????????,???,??????????????????????????????HER2??????????,ADC??,???????????‘1+1>2’??????????,??”

HER2???????45%???55%???,???HER2?????????,?????HER2?????????????????,?????????????HER2????????????????????????:“???HER2???????????,??ADC????HER2?????HER2????????????,?????????????????,??????HER2?????????????????????????,??????,????”

?,ADC??????????????,?????????????,ADC??????;????

?????????????????,???????????????2017??????,??????????????????????,?,??,???????????????????:“???????????,???????????,????”

??????????????????????,???????,??,????,???,??????:???????????????????????????????????????????????????,?????????????,???????40?????????????B????,???????????????????????,???:?????????????????????40????,???????????????????,?????(???????) ???????:????????????