??????????????

????:????????????:????wx

???????????2025?2?????????21???????????,?«????»????“Base-modified nucleotides mediate immune signaling in bacteria(???)”???????????(????)?,?????“???”(Kongming),????“??”????????????,?????????????????????

???????,???????????????????????????????????,?“?????????????”????????????1950??(??????????????????cAMP?cGMP)?????????,????????????????,?????????,????????????????????????,????,??????KomA(????A)?KomB(??B)?KomC(??????????C)???????????,???(DNK)????????????“?”:KomA????DNK??????????????????,????????????????????(dAMP)??dITP??????????KomC??????????NAD⁺,??????“??”????????????????????,??,???????????“??”??????,?“????????????????”?????,????????

??,“??????????”?????????????????????????????????????,??(?????KomB-KomC????KomA)??????????,????dITP??????:?,??????????????????(?????????????????ADA?????????????????)??,???

(?????????????????? ????????????????? ???????????????) ?????????????:????????????????????????