???2025??????????????????2?21???????????,??«??»????“Base-modified nucleotides mediate immune signaling in bacteria(?????????????????????)”??????(??????)??????????,?“??????”(Kongming),??“????”???????????,????????????????????????

????,??????,???“?????????????????”??????1950????????????????????????????(??cAMP?cGMP)????,????????????????,?????????????,??????????????????,??,??????KomA(??????????????????A)?KomB(????B)?KomC(?????????C)???????????????????????????????????????????????????,??(DNK)??????“???????????????”:KomA?????????????????DNK?,?????????????(dAMP)????dITP??KomC????NAD⁺,?“?????????”??????????,??????????,???????“????????????????????”????????????,??????“?????????????????”???,????

??,“??”????????????????????,?????????(????????????KomB-KomC??KomA)?????????????????????????,?dITP????????????????:???????,?????????????(??ADA??????????????????)??,???????????

(??????? ??? ????) ?????????????:??? ??“?????”

?? ??????????????

????:1??????:????spa?

2??????????

3?????????

4????????vx

5????????

???2025??????????????????2?21???????????,??«??»????“Base-modified nucleotides mediate immune signaling in bacteria(?????????????????????)”??????(??????)??????????,?“??????”(Kongming),??“????”???????????,????????????????????????

????,??????,???“?????????????????”??????1950????????????????????????????(??cAMP?cGMP)????,????????????????,?????????????,??????????????????,??,??????KomA(??????????????????A)?KomB(????B)?KomC(?????????C)???????????????????????????????????????????????????,??(DNK)??????“???????????????”:KomA?????????????????DNK?,?????????????(dAMP)????dITP??KomC????NAD⁺,?“?????????”??????????,??????????,???????“????????????????????”????????????,??????“?????????????????”???,????

??,“??”????????????????????,?????????(????????????KomB-KomC??KomA)?????????????????????????,?dITP????????????????:???????,?????????????(??ADA??????????????????)??,???????????

(??????? ??? ????) ?????????????:???