???????????????

??

????1???????????14?????? (?? ??????)“???,???????????????,?????????”????14???????,“?(ADC)???????????????????????,??????,????????????????????????????,????”

????????????????,?????????????,???????????????????,?????????????,?,“?????”??

??????????,?????????????????????????,??,??????:?????????????????????????????????,???????????????????,??????????????20%??30%?????????????????,?:???“?????,?????”??????,???????,???????????????????????

????,??????????????,??:????????,???????????????,??????????????????????????????,?????????????????????????????????????????,????????,???????,?????????????????,????,??,??,???????

??????,????????????????-2(HER2)?????,??????“HER2??????”?????????????“HER2??”???????????????????????,????????????HER2??????????????,??????HER2??????????,HER2???????

??????????????,?????????????,HER2?????????20%??????????,?????????????????,????????????????,ADC??????????????“HER2??????HER2?????????,??ADC???????,?????????,????????????????????????????HER2???????????????,ADC???,?‘1+1>2’??,?????????????????????”

HER2??????45%?????????????55%?????????????,?????????????????HER2????????????????????????????,?HER2?????????,??????????HER2???????????????????????:“????????????HER2?,??ADC?HER2????????????HER2??????????,?,??HER2?????????????????????????,????,?????????????”

??,ADC??????,????????,ADC????????????????;???

??????,????2017?????,?????,???,????????,????????????????????:“??,?????,????”

??,???????????????,?,??????????????,???,??????????:?????????????????????????????????????????????????????????????????????,?????????????,??40?????????????B?????????????,??????????????,??????:????????????????40??????,???????,???????????(??) ????:???????

?????????

?????????????????????????

????????