??? (???????)12???????????????8??????????????,?,??????????????????????????????,??????????,???????????????????????????,??????????????,???????????????????????

???,??????????,?????????????????????,?,?????????????????????(AFP)??????,????????19(CYFRA21-1)???????????,??(CEA)?????????????

?,???????,?????????????????,???????“????”??,????????????????

??,??,??????????????????10??????????????????,??????

?,?????,???????????????,?????????????50?????????????,???????????,??????,??10%?

???????????????????,????,??????,??????????,?????????,?????,?????????????????

???????12??????????2????????,????????????????????????????????17????,??????????????????11???30????????????????????????,????????,????????????????????????,?(ProGRP)?149????????/?,??????????40?????/???,?????,??50????,??????????????????,??????????,????????????????????????,?????????????????,????????,??????????????????????

“????,?,???????????”???????????,?,???,?????,???????????

??????????????????? 1

??“?”

???????????“?”,?????????????????,?“???????????????”,????????,?????

??,?????(?????????????CA125?????CA19-9??????????PSA)??,??????,??500?????????220?????,???????127???50???,???????????,???????????????“??”?

????????,???,??????,?????????“??????????????????????????????????????????????”?

? 2

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??????????,????????????????,???????,???

????????????????,???????,??????????????????????19?????CT??????,???????????????????,?????????????????“??”???????????,?108??50????????????????????????,??????????19???????????155????????50???,???????????????????????163?????

???? 3

?

??,?????????“?????????”??????,?,????????????????????????????????

??????????1-3???,????????(TPSA)?????????(FPSA)???,??960??,?2880???????,??????,??????????????????,?400??,???1680????,?????????????????????????????????????

¦ ???????????????????

??91???????26?

??,2024???????????????????,??,???91???????26?????????????,??????????????,???

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??????“ADC?????”??????“???”??????????????????,???????2024?????????6????20??????????,????????????????100mg/???????????????8860?????????????6912?????????????,?22%???????,55kg?????????3???????????????????,??????6000???????????????????????????,???10????????????

?????????????????,????????????,??????,????????????????,?40????????14.9%,??35???????6.5%;??????2%,??????????????

?????,??????????????????????????????????,???????????????50???????,????13220???????????/125mg/??????????6166???????????????????/125mg/???????,??53.4%;“????”??????????? ???????:??????????? ??“???????”????

?? ??????????????

????:1????????:?????????

2?????????95

3????????????

4??????????

5???????????

??? (???????)12???????????????8??????????????,?,??????????????????????????????,??????????,???????????????????????????,??????????????,???????????????????????

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?,???????,?????????????????,???????“????”??,????????????????

??,??,??????????????????10??????????????????,??????

?,?????,???????????????,?????????????50?????????????,???????????,??????,??10%?

???????????????????,????,??????,??????????,?????????,?????,?????????????????

???????12??????????2????????,????????????????????????????????17????,??????????????????11???30????????????????????????,????????,????????????????????????,?(ProGRP)?149????????/?,??????????40?????/???,?????,??50????,??????????????????,??????????,????????????????????????,?????????????????,????????,??????????????????????

“????,?,???????????”???????????,?,???,?????,???????????

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???????????“?”,?????????????????,?“???????????????”,????????,?????

??,?????(?????????????CA125?????CA19-9??????????PSA)??,??????,??500?????????220?????,???????127???50???,???????????,???????????????“??”?

????????,???,??????,?????????“??????????????????????????????????????????????”?

? 2

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??????????,????????????????,???????,???

????????????????,???????,??????????????????????19?????CT??????,???????????????????,?????????????????“??”???????????,?108??50????????????????????????,??????????19???????????155????????50???,???????????????????????163?????

???? 3

?

??,?????????“?????????”??????,?,????????????????????????????????

??????????1-3???,????????(TPSA)?????????(FPSA)???,??960??,?2880???????,??????,??????????????????,?400??,???1680????,?????????????????????????????????????

¦ ???????????????????

??91???????26?

??,2024???????????????????,??,???91???????26?????????????,??????????????,???

????????ADC?PD-1/PD-L1?????PD-1/VEGFA?,???????????????????HR?/HER2????

??????“ADC?????”??????“???”??????????????????,???????2024?????????6????20??????????,????????????????100mg/???????????????8860?????????????6912?????????????,?22%???????,55kg?????????3???????????????????,??????6000???????????????????????????,???10????????????

?????????????????,????????????,??????,????????????????,?40????????14.9%,??35???????6.5%;??????2%,??????????????

?????,??????????????????????????????????,???????????????50???????,????13220???????????/125mg/??????????6166???????????????????/125mg/???????,??53.4%;“????”??????????? ???????:???????????