????????????????12????5???????????????????? ??????,??????????????????????????????????????????????????3b??????????????????SURMOUNT-5?????????topline???????????????????????????,??????????(tirzepatide)???????????(semaglutide)?,?????????1.47????????????????????

??,???????20.2%,???????????????13.7%i???72????,?,??5?????????????,?????????

???????, ?????????????,?GIP????????????GLP-1???GIP???GLP-1??????????????????????????????(CKD)?????????????????(MMO)??????????????????????????????????,?(FDA)????(OSA)?????????????(FDA)??????????(HFpEF)???

??????2022???????????????5??13????????(FDA)?????,???2????????????????????????????;2023??????????????11???????????????????8?????????????????????,FDA??????????????????????????????????(BMI=30kg/m2)??(BMI=27kg/m2)?????????????

???????????????????????GIP(????????????????????????)???GLP-1(????????????-1)???????????????,??????????????????

“????????,????,???,”?????Leonard C. Glass???????????????????????,“????????????,????,?????????????????????????,???????????????1.47????????????????FDA????????????????GIP/GLP-1???,??”

?????:“???????????,??????,???????????????”

??????????????????,?????????,?????????????????????????????31.6%??????25%,???????????????16.1%????????????

?????????????????SURMOUNT-5????????,??????????????????????SURMOUNT????????????????????????????,????????????????

????????????SURMOUNT-5?,????????????????????????

?????????????????,SURMOUNT-5(NCT05822830) ?????????????????????????????????3b ???,?????(??????????????????????)?????,????(tirzepatide)??????????(semaglutide)???????????751??????????????,???1:1?????,??(10mg???????15mg)??????????(1.7mg?????????2.4mg)??????????????????????????????????72???,??????

i???????????(treatment-regimen estimand)???????,?????????,???????????????(????????????????)????????????????,??,??? ?????:?? 上海新茶论坛后花园海选

?? ????????????20.2% ???????????????13.7%

????:1?????:?????95???

2?????????

3?????95?

4??????????

5?????

????????????????12????5???????????????????? ??????,??????????????????????????????????????????????????3b??????????????????SURMOUNT-5?????????topline???????????????????????????,??????????(tirzepatide)???????????(semaglutide)?,?????????1.47????????????????????

??,???????20.2%,???????????????13.7%i???72????,?,??5?????????????,?????????

???????, ?????????????,?GIP????????????GLP-1???GIP???GLP-1??????????????????????????????(CKD)?????????????????(MMO)??????????????????????????????????,?(FDA)????(OSA)?????????????(FDA)??????????(HFpEF)???

??????2022???????????????5??13????????(FDA)?????,???2????????????????????????????;2023??????????????11???????????????????8?????????????????????,FDA??????????????????????????????????(BMI=30kg/m2)??(BMI=27kg/m2)?????????????

???????????????????????GIP(????????????????????????)???GLP-1(????????????-1)???????????????,??????????????????

“????????,????,???,”?????Leonard C. Glass???????????????????????,“????????????,????,?????????????????????????,???????????????1.47????????????????FDA????????????????GIP/GLP-1???,??”

?????:“???????????,??????,???????????????”

??????????????????,?????????,?????????????????????????????31.6%??????25%,???????????????16.1%????????????

?????????????????SURMOUNT-5????????,??????????????????????SURMOUNT????????????????????????????,????????????????

????????????SURMOUNT-5?,????????????????????????

?????????????????,SURMOUNT-5(NCT05822830) ?????????????????????????????????3b ???,?????(??????????????????????)?????,????(tirzepatide)??????????(semaglutide)???????????751??????????????,???1:1?????,??(10mg???????15mg)??????????(1.7mg?????????2.4mg)??????????????????????????????????72???,??????

i???????????(treatment-regimen estimand)???????,?????????,???????????????(????????????????)????????????????,??,??? ?????:??