?? ????????????20.2% ???????????????13.7%
????:1?????:?????95???
2?????????
3?????95?
4??????????
5?????
????????????????12????5???????????????????? ??????,??????????????????????????????????????????????????3b??????????????????SURMOUNT-5?????????topline???????????????????????????,??????????(tirzepatide)???????????(semaglutide)?,?????????1.47????????????????????
??,???????20.2%,???????????????13.7%i???72????,?,??5?????????????,?????????
???????, ?????????????,?GIP????????????GLP-1???GIP???GLP-1??????????????????????????????(CKD)?????????????????(MMO)??????????????????????????????????,?(FDA)????(OSA)?????????????(FDA)??????????(HFpEF)???
??????2022???????????????5??13????????(FDA)?????,???2????????????????????????????;2023??????????????11???????????????????8?????????????????????,FDA??????????????????????????????????(BMI=30kg/m2)??(BMI=27kg/m2)?????????????
???????????????????????GIP(????????????????????????)???GLP-1(????????????-1)???????????????,??????????????????
“????????,????,???,”?????Leonard C. Glass???????????????????????,“????????????,????,?????????????????????????,???????????????1.47????????????????FDA????????????????GIP/GLP-1???,??”
?????:“???????????,??????,???????????????”
??????????????????,?????????,?????????????????????????????31.6%??????25%,???????????????16.1%????????????
?????????????????SURMOUNT-5????????,??????????????????????SURMOUNT????????????????????????????,????????????????
????????????SURMOUNT-5?,????????????????????????
?????????????????,SURMOUNT-5(NCT05822830) ?????????????????????????????????3b ???,?????(??????????????????????)?????,????(tirzepatide)??????????(semaglutide)???????????751??????????????,???1:1?????,??(10mg???????15mg)??????????(1.7mg?????????2.4mg)??????????????????????????????????72???,??????
i???????????(treatment-regimen estimand)???????,?????????,???????????????(????????????????)????????????????,??,??? ?????:??