??????????????

??2025????2????????????????????21?????????????,???????????????«??????????????????»??“Base-modified nucleotides mediate immune signaling in bacteria(?????????????????)”???????????????????(????????????????????????????)??????????????????,??????????“?”(Kongming),??????“?”????,???

??????????????????,?????????????,?????????????????“?????”????1950????????????(????cAMP?cGMP)??????????,???????????,???????????,????????????????????,??,????KomA(???????????A)?KomB(?B)?KomC(??????C)???????????????,??(DNK)??????“????”:KomA??????DNK????????????,???(dAMP)?????????dITP????????????KomC????NAD⁺,????“?????????????”?????????????????????????????,??????,???“????”????????????????????,???“??????????????????”????????????,??????????????????????????????????????

?????????????????,“??????”?????????????,?(?KomB-KomC????KomA)???????,??dITP???????????????????????:??,??(??ADA??)???????????,??????

(????????? ?? ??) ??:???????