?????????????2025???????????????2??21????????????????????,???????????«????»????????????“Base-modified nucleotides mediate immune signaling in bacteria(??????????????????)”????????????????????????(?)????,??????“??”(Kongming),????“??”?????????,???

??????????,??????????????????????,?????????????????“??????????”????1950??(???cAMP?cGMP)????????????,?????????????????????,???????????,???????????????????????????,???,??????KomA(??????????????????A)?KomB(??B)?KomC(?????C)?????????????,????(DNK)?????????“?”:KomA??????????????????DNK???????,????(dAMP)????dITP???KomC????????????????????????????NAD⁺,????“?”????????????????,?,??????“???????”????????????,?“????????????????”???,???????

?????,“????”?,???????????(??????KomB-KomC??KomA)???????????????????????????????????????????????????????????,??dITP???:??????,?????????????(??ADA??????????????????)?,??????????????????

(?? ?? ??) ?????:???????????????????????? “????????????”_????

?? ??????????????

????:1?????????????:???????????

2??????

3?????????

4??????24????

5?????

?????????????2025???????????????2??21????????????????????,???????????«????»????????????“Base-modified nucleotides mediate immune signaling in bacteria(??????????????????)”????????????????????????(?)????,??????“??”(Kongming),????“??”?????????,???

??????????,??????????????????????,?????????????????“??????????”????1950??(???cAMP?cGMP)????????????,?????????????????????,???????????,???????????????????????????,???,??????KomA(??????????????????A)?KomB(??B)?KomC(?????C)?????????????,????(DNK)?????????“?”:KomA??????????????????DNK???????,????(dAMP)????dITP???KomC????????????????????????????NAD⁺,????“?”????????????????,?,??????“???????”????????????,?“????????????????”???,???????

?????,“????”?,???????????(??????KomB-KomC??KomA)???????????????????????????????????????????????????????????,??dITP???:??????,?????????????(??ADA??????????????????)?,??????????????????

(?? ?? ??) ?????:????????????????????????