??????????????

??

?????????2025????2???????????21??????????????????,??????????????????«????????????????????????????»?????????????“Base-modified nucleotides mediate immune signaling in bacteria(??????)”?????????????????????????????????????(??)??????,??“????”(Kongming),????“????”????,??

?????????,????????,????“???”?????????????????????1950????????????(?cAMP?cGMP)??,?????????????,???????????????????????,?????,????,???KomA(??A)?KomB(??????B)?KomC(???????C)?????????????,???????????(DNK)?????????????????“??????”:KomA?????????????????????????????????????DNK??,????????????(dAMP)??????dITP???KomC??NAD⁺,??????“??????”????????????????????????,???????????????,?????“???????”?????,???“?”??,?????

?,“????”???????????,????(??KomB-KomC????????????????????KomA)???????????????????????????????????,???????dITP?????????????:???????????,??????(?ADA??????)?????????,???

(??? ????????????????? ?) ???????????????????:??????????????????

?????????

????????????????????????

????????