??????????????????2025???????2??21?????????????????,?????«??????????????????»??????????“Base-modified nucleotides mediate immune signaling in bacteria(??????????????????)”??????????????(??????)??????,????????????????????“?????????????????????”(Kongming),??“?????????????”?????????????,???????

????,??????,??“????”????????????????1950??(???????cAMP?cGMP)?,??????????????,??????????????,????????,????????????,???????????KomA(??????A)?KomB(??B)?KomC(??????C)????????????????????,?????????(DNK)?????????“???????????????????????”:KomA?????????????DNK?????????????????????????????????????,????(dAMP)?dITP????KomC??????????NAD⁺,????“?”????????????????????,???,??“??”?,???“?”??????,?????????????

????,“????”?????????????????,????????????????????????????(??????KomB-KomC????KomA)?????,????dITP????????????:???????????,??(????ADA???????????)??????????,???????????????????

(?? ? ????????????????????) ?????:???????

??

??:???????????,??????????,??????????????