??????????????
??
??????2025????2??????21?????????????,????«??»??“Base-modified nucleotides mediate immune signaling in bacteria(??????)”???????????????????????(????????????)??????????????????,??????“??????????????????”(Kongming),???????????“????????????”?????,???????
??????,??????????????,????“???”???1950???????????????(????????????????????cAMP?cGMP)?????,??????????????????????,?????????????,????????????,?????????????,??KomA(????A)?KomB(????B)?KomC(?????????????????C)???????????,?(DNK)???????“?”:KomA??DNK????????????????,???(dAMP)?????????????????????dITP????????????KomC????NAD⁺,???????“?????????????????”??????????????,??????,?“?????????”?,??????????“????????????”??,???
?,“??????????????????”????,??(???????KomB-KomC?????????????????????????????????????KomA)??????????????????????????????????,??dITP??:??,????????????????????????????(???????????ADA?)???????????,???
(??????????????????????? ??? ??????) ???:????
?????????
????????????????????????????????
????
- 1???:??????????????????
- 2????????:????????????
- 3?????????????????
- 4??????????????????????????
- 5??:???????????21????
- 6?????????1???????????
- 7??????????????:??7????
- 8??????????????????
- 9??:?????????????
- 10?????4?1?????????9????
- 11??????????????????????
- 12??|????????!??????????
- 13?????????????????????
- 14??????!????????:???3??
- 15??????????????????????????
- 16????:???????????iOS
- 17???????????????????
- 18??:??????????????????
- 19MVP?????!?????????????
- 20????????:????????????