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????????????2025??????2????21???????????,??????«??»???“Base-modified nucleotides mediate immune signaling in bacteria(??)”?????????????(??????????)???????????,?????????????????“?????????????”(Kongming),???“???????”???????????????,??????????????????

???????????,???????,??????“?”?????????????1950?????????????(????cAMP?cGMP)??????????????????,?????????,??????????,??????????????????????,????,????????????????????????????KomA(??A)?KomB(??B)?KomC(??????C)?????,??(DNK)????“?????????????????”:KomA??DNK??,??(dAMP)??????????dITP?????KomC?????????NAD⁺,?????????“?”????????????,??????,????“?????”?????????????????????????????????????,??“??????????????????”??,?????

????????????????,“????????????”???,????????????????????(?KomB-KomC???????????????????????KomA)???????,??????????dITP???:????,?????????????????????(??????ADA??????????????????)?????????????,???????

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