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????2025???2????21???????????,??«??»??????“Base-modified nucleotides mediate immune signaling in bacteria(?????????)”??????????????????????????????????????????(??????????????????)?,???????????“???”(Kongming),???????????????“????”??????,?????????????????????????????

??????????,????????????????????????????????,?“???????”?????????????????1950????(???????????cAMP?cGMP)??????????????????,???????,???????????????????,??????????????????????????,???,?????????????KomA(?A)?KomB(??B)?KomC(??????C)????????????????????,??????(DNK)??????“?????????????????”:KomA?????????????????????????????????????DNK??????,??(dAMP)?????dITP???KomC????NAD⁺,??“??????”????,?????????,????????????“?????????????????”?,?????????????“???”???,?????????????

??????????,“????”??????,??????(?????????????????????KomB-KomC???????KomA)???????,?????????dITP??:??????????????????,????(??ADA??)??,?????

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