??2025???????????????????????2????21???????,?«???»???????????????“Base-modified nucleotides mediate immune signaling in bacteria(????????????)”???????????????????????????????????(????)??????????????????,???????????“?????”(Kongming),???????????“???”????,???

?,????????????????????,??“????????????????????”?????????????1950????????????????????(??????cAMP?cGMP)???,?????????????????????????,??????????????,????????????????,?????????,???????????KomA(???????????A)?KomB(?????????????B)?KomC(??????????????????C)?????????????????????,?(DNK)?????????????“?”:KomA??DNK??????,??????(dAMP)??????????????????dITP???KomC?NAD⁺,??????????“??”????????????????????????????,??,????“??????”??,?????????????????“????”????????,???

??,“?”??????????????????,????(???????KomB-KomC?????KomA)???????????,?????????????????dITP????:??????,??????(??ADA????)??,???

(????????????????????????????????????? ?????? ????) ???:???????????

??

??:???????????,??????????,??????????????