?? ????????????20.2% ???????????????13.7%
????:1???????????:???95?98???
2?????
3?2020??????????
4?????????????
5???????
???????????????????12??5?????? ???????????????????,??????????????????????????????????????????3b????????????SURMOUNT-5??????topline???????????????????????????????????????,????????(tirzepatide)????????????????????(semaglutide)?????????,???????????1.47????????????????
?????????????,??????????????20.2%,???13.7%i??????????????????????????????72?,???????????,??5??,????
??????????????????????, ????????????????????,????????GIP??GLP-1???????????GIP???????????GLP-1??????????????????????(CKD)?????(MMO)????,??(FDA)?????(OSA)??????????????????????????????????(FDA)?(HFpEF)?????????????
????2022??5?????????????????13???????????????(FDA)??????????,??????????????????2?????????????????;2023?11???????????????8???????????????????????,FDA?(BMI=30kg/m2)??(BMI=27kg/m2)??????
??????????????????GIP(??)??GLP-1(???????????????-1)???????????????????????????????,???????????????????????????????????
“????????????????????,?????,??,”???????????????Leonard C. Glass??????,“?,?,????????????????????????????,?????????????1.47??????????????FDA????GIP/GLP-1????????,?????????”
???????:“???????????????????????????????????????????,????????????????,?????????????”
?????????,?????????????????,?????????????31.6%?????25%,?16.1%????
??????????????SURMOUNT-5?????????????????,???SURMOUNT?????????,????????
???????????????SURMOUNT-5?????????????????????,??????????????????
???,SURMOUNT-5(NCT05822830) ????????????????????3b ?????,??????(???????????????????????????????????)???,????(tirzepatide)??????????(semaglutide)?????????????????????751????????????????????????????,??????1:1?,?????????(10mg????????????15mg)????????????????(1.7mg??2.4mg)??????????????72??????????????,????????
i?????????????????????????(treatment-regimen estimand)??,?,????(?????)?????????????,??,????????????? ????:????????????????????????