????:1????95??:????????

2???90???????

3?????wx

4???????????

5????????????

??????2025?????????????????????????????????????2????21?????,??????«????»???????????“Base-modified nucleotides mediate immune signaling in bacteria(???)”?????????????????????(?)?????????????????,?“??”(Kongming),??“??”??,???

?????????????????????,?????,??????????????????“??????”?????1950??????????(??????????????????cAMP?cGMP)????,????????????????,????????????????????????,?????????????????????????,????????????,???KomA(????A)?KomB(????????????B)?KomC(?????????C)???????????????????,??(DNK)?????????“???????”:KomA????????????????????DNK??????????,??(dAMP)??????dITP????????????KomC???????????NAD⁺,????“?????????????”????????,??,?????????“???????”?,?“??”????,???

??,“?”???,???????(????????????????????KomB-KomC????????????KomA)???????????,??????????????????dITP????????????????????????????:?????????????,???????????(???????????????????????ADA????)?????????????????,??????

(?????????? ? ??????) ?????:?????