??????????????

????:??????:??95??

???????????2025????????????2????21?,???????????«??????????????????»??“Base-modified nucleotides mediate immune signaling in bacteria(??????)”????????????????(?)?????????????????????????????????????,??“????”(Kongming),?“??????????”????,????????????????

??,?????,??“??????”???????1950????(????cAMP?cGMP)???,??????????????????????????????????????,?????????????????,??????????????????,?,??KomA(??????????A)?KomB(??B)?KomC(????????????C)???????????????????????????,??????????????????(DNK)????“?????????????????????”:KomA??????DNK????,???????(dAMP)??????dITP??????KomC?NAD⁺,???????????????????????“?”??????????????????????,????????????????????,??“?????????????????”????????????,???“??????”?????,??????????????

??????????????????,“??”??,?????(???????KomB-KomC??KomA)?????????????????????,???dITP??:????,??????????(????????????????ADA???)?,??????????

(??????????? ???? ?????????????) ????????:??????????????????