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??????????2025?????????????????????2??21?,????«???????????????»??“Base-modified nucleotides mediate immune signaling in bacteria(????)”??????(?)????,???“?????????????”(Kongming),???“?????????????????”???????,?????????????????????????????

??????,???????????????,??????“??”???????????????????1950????(?cAMP?cGMP)????,?????????????????,???????????,???????????????????????????????????????,??????,???KomA(??A)?KomB(??????B)?KomC(??C)??????????????,????????????????(DNK)??“???????????????????????”:KomA????DNK?????,??(dAMP)??dITP??????????????????????????????????????KomC??NAD⁺,??????????“????”????????????????????,????,??????????????????“???????”?????????????,???“?????????”???????,??????????

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