??????????????
??
?????2025?????????????????2??????21??????????????????,????«?»????“Base-modified nucleotides mediate immune signaling in bacteria(?)”??????????????(????)?,????“??????????”(Kongming),???????????????????????“??”??????,????????????????
???????,??????????????????????????????????,????“???”????????????1950??????(???????cAMP?cGMP)???,?????,???????????????,????????????????,??,??KomA(?????A)?KomB(?????????????????????????????????????B)?KomC(??????????C)??????????????,?????????(DNK)??????“??????????????????”:KomA???????????DNK?????????????????????,??(dAMP)?dITP???KomC???????????NAD⁺,????“?”???????,????,?“????????????????????????????”???,????“??????”???,?????????????????????
????,“??????????”??????,??????(?????????????????KomB-KomC????????????????????KomA)????????????????????????????????,??dITP??:????????????,??(??ADA??)????,?????
(????????? ?????????????????? ????????????) ?????????????:??????????????
?????????
????????????????????????????????
????
- 1???:?????3?????????????
- 24?10??????????10????13?
- 3???100?????3???????
- 4??:??????????????????
- 5???????????????????
- 6??????????????????
- 7????:??“??????”?????????
- 8???:??????????????????
- 9????:????????????????3.3?
- 10????????!???????????
- 11??????:?????????????
- 12?????20????????????????
- 13???????????300??????(?)
- 14????????????????????
- 15???????????????:????
- 16??-???????????????2-1??
- 17???:??????????????????
- 18???????????3?????????
- 19??????????????:???????
- 20??:???????9????7???????