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??????????2025?????????????????????????????????????2?????21??,????«????????????????????»????“Base-modified nucleotides mediate immune signaling in bacteria(???????)”????????????????(?)??????,????“????????????????????????????”(Kongming),??“??????”??????????????????,??????????????????
??,??????????????,?????????????“?”???????1950???????????(???cAMP?cGMP)??,????????????????????????????,??????????????????,??????????????,????,????????????KomA(??????A)?KomB(?????????????B)?KomC(??C)????????????????,?(DNK)?“??”:KomA??????????????????DNK??,?????????(dAMP)??dITP?????KomC??????????NAD⁺,??????“???????”????????,??????????????????,????“???”??????????????????,??“?????”???????,???
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- 2????“??????”?????????????
- 3??????????4?????4U23???
- 4??????????????????
- 5???????????????????
- 6??????9???????????????
- 7???????22?????:3??????????
- 8????????????????????
- 9??-???????????????2-1??
- 10????:3???????????????
- 11???:?????3?????????????
- 124?10??????????10????13?
- 13??-4???????????1-2??????
- 14????????:???????NBA???
- 15???3?????????????????
- 16???????????????????
- 17???????????????1?3?
- 18????“??????”?????????????
- 19???3?????????????????
- 20????:??“??????”?????????