??????????????

?2025????????????2?21??,??«????????????????»?????“Base-modified nucleotides mediate immune signaling in bacteria(?)”?????????????????????????????????(???)????,?????????????????????????????????????“???????”(Kongming),??“????????????????????”??,??????????????

??????,?????????,???????“?????????????????”????1950??????(???????????cAMP?cGMP)??????,???????????????????,?????,????????????,?????????????????,??????????KomA(???????????A)?KomB(??????B)?KomC(?????????????????????C)???????????,?(DNK)??????????????????“????”:KomA????????????????????????????DNK????????????????????,??????????????????(dAMP)????dITP???KomC??????NAD⁺,??????“?”???????????????,????,??????????????????“???”????????????,???“??????????”?????,??????

??????,“??????????”????,?????????????(??????KomB-KomC????KomA)??????????????,??dITP?????????????:????,???????????????(??????????????????ADA???????????)??,???

(?? ?? ????) ????:????????????