????:1??????95???:??????wx

2??????????

3?????????????

4?????

5??????????

????????????????2025????????????????????????????2??21?,????«????»??????????????????“Base-modified nucleotides mediate immune signaling in bacteria(?????????)”??????????(???????)??,??????“??”(Kongming),??????????“???”????,?????????????

?,????????????????,?????????????????“??”?????1950???????????(?????????cAMP?cGMP)??????????,??????????????,??????????????????,????????????????,??????,????????????KomA(?A)?KomB(??????????B)?KomC(?????????????????????????????????????C)???????,???????(DNK)?????“????????????????????”:KomA??????????????????DNK??????,???(dAMP)?????????????????dITP???????????????????KomC??????NAD⁺,???????????“????????????????????”????????????????????,???,???“?”?,??????“??”?????,?????

???,“??????”?????????,???????????????????????(??KomB-KomC?KomA)????????????????????????,?????dITP??????:????,??(?????????????ADA????)?????????????,???????

(???????????? ?? ????) ???????:??????????????????