?? ????????????20.2% ???????????????13.7%
????:1??????:??????
2?????
3?????????
4??????????
5???????
??????12????????????????5?????????????? ??????????????,???????????????????????????????3b????SURMOUNT-5???????????????topline????????,????(tirzepatide)?????(semaglutide)?????????????,???1.47???????
????,??????????????????????20.2%,?????????13.7%i??72???,????????????????????,????????????5??????,?????????????????????????????????
????????????????????????, ??,??????GIP??GLP-1??????GIP????GLP-1???????(CKD)???????(MMO)?????????????????,????(FDA)?????(OSA)???????(FDA)???????????????????????(HFpEF)?????
????2022????????????????5?13?????????????????(FDA)???????????????,??2?????????;2023???????????????????11????????8???????????????,FDA?????????????(BMI=30kg/m2)??(BMI=27kg/m2)????????????????
?????GIP(???????????)??GLP-1(???????????-1)????????????????????????,???????????????????????
“?,?????????????????????,?,”????????????????????????????Leonard C. Glass????????????????,“??????,???????????????????????,????????????????????????????????????,?????????????????????????1.47???????????????????????FDA????????GIP/GLP-1??????????,??????????????”
????:“??????????????????????,???????????????,???????????????????????????????????????????????”
??,????????????????????,???31.6%?????25%,???16.1%??????????????????
??????????SURMOUNT-5????????,???????SURMOUNT????,???
?????SURMOUNT-5???????????????????????,??????????
????????,SURMOUNT-5(NCT05822830) ??????????????????3b ???????????????,??(?????????????????????)?,??????????????????(tirzepatide)?(semaglutide)??????????751??????????????,???1:1??????,?????????(10mg??????????????15mg)?????????????????(1.7mg??????????2.4mg)?????????????????????????72????,?????????????
i?????????(treatment-regimen estimand)??????????????????????????????,?????,?(??????????????????????????????????)????,???????????,????????????? ????????:????????????????????????