??????12????????????????5?????????????? ??????????????,???????????????????????????????3b????SURMOUNT-5???????????????topline????????,????(tirzepatide)?????(semaglutide)?????????????,???1.47???????

????,??????????????????????20.2%,?????????13.7%i??72???,????????????????????,????????????5??????,?????????????????????????????????

????????????????????????, ??,??????GIP??GLP-1??????GIP????GLP-1???????(CKD)???????(MMO)?????????????????,????(FDA)?????(OSA)???????(FDA)???????????????????????(HFpEF)?????

????2022????????????????5?13?????????????????(FDA)???????????????,??2?????????;2023???????????????????11????????8???????????????,FDA?????????????(BMI=30kg/m2)??(BMI=27kg/m2)????????????????

?????GIP(???????????)??GLP-1(???????????-1)????????????????????????,???????????????????????

“?,?????????????????????,?,”????????????????????????????Leonard C. Glass????????????????,“??????,???????????????????????,????????????????????????????????????,?????????????????????????1.47???????????????????????FDA????????GIP/GLP-1??????????,??????????????”

????:“??????????????????????,???????????????,???????????????????????????????????????????????”

??,????????????????????,???31.6%?????25%,???16.1%??????????????????

??????????SURMOUNT-5????????,???????SURMOUNT????,???

?????SURMOUNT-5???????????????????????,??????????

????????,SURMOUNT-5(NCT05822830) ??????????????????3b ???????????????,??(?????????????????????)?,??????????????????(tirzepatide)?(semaglutide)??????????751??????????????,???1:1??????,?????????(10mg??????????????15mg)?????????????????(1.7mg??????????2.4mg)?????????????????????????72????,?????????????

i?????????(treatment-regimen estimand)??????????????????????????????,?????,?(??????????????????????????????????)????,???????????,????????????? ????????:???????????????????????? “?????”_????

?? ????????????20.2% ???????????????13.7%

????:1??????:??????

2?????

3?????????

4??????????

5???????

??????12????????????????5?????????????? ??????????????,???????????????????????????????3b????SURMOUNT-5???????????????topline????????,????(tirzepatide)?????(semaglutide)?????????????,???1.47???????

????,??????????????????????20.2%,?????????13.7%i??72???,????????????????????,????????????5??????,?????????????????????????????????

????????????????????????, ??,??????GIP??GLP-1??????GIP????GLP-1???????(CKD)???????(MMO)?????????????????,????(FDA)?????(OSA)???????(FDA)???????????????????????(HFpEF)?????

????2022????????????????5?13?????????????????(FDA)???????????????,??2?????????;2023???????????????????11????????8???????????????,FDA?????????????(BMI=30kg/m2)??(BMI=27kg/m2)????????????????

?????GIP(???????????)??GLP-1(???????????-1)????????????????????????,???????????????????????

“?,?????????????????????,?,”????????????????????????????Leonard C. Glass????????????????,“??????,???????????????????????,????????????????????????????????????,?????????????????????????1.47???????????????????????FDA????????GIP/GLP-1??????????,??????????????”

????:“??????????????????????,???????????????,???????????????????????????????????????????????”

??,????????????????????,???31.6%?????25%,???16.1%??????????????????

??????????SURMOUNT-5????????,???????SURMOUNT????,???

?????SURMOUNT-5???????????????????????,??????????

????????,SURMOUNT-5(NCT05822830) ??????????????????3b ???????????????,??(?????????????????????)?,??????????????????(tirzepatide)?(semaglutide)??????????751??????????????,???1:1??????,?????????(10mg??????????????15mg)?????????????????(1.7mg??????????2.4mg)?????????????????????????72????,?????????????

i?????????(treatment-regimen estimand)??????????????????????????????,?????,?(??????????????????????????????????)????,???????????,????????????? ????????:????????????????????????