??????2025???????2??????21??????????,??????«??????????»?????????“Base-modified nucleotides mediate immune signaling in bacteria(??)”?????????????????????(????)?????,??“????”(Kongming),???????????“????”?,??????????????

??,?????????????????????????????????,??“??”???????1950?(??????????cAMP?cGMP)??,????????????????????????????????????,????????????????????,?????????,?,??KomA(???A)?KomB(?????????????????B)?KomC(??????????????????C)??????????,???????????(DNK)????“???????????????????????”:KomA????DNK???????,?(dAMP)?dITP????????KomC??NAD⁺,???????????“?”??????????????????????,??????,????????????“???”????,?????????????????????????????????????“?????????????????????”??????????,?????

???????????,“?????????????????”??????????????????,??(??KomB-KomC??????KomA)???????,?????????dITP?????????????:????????????????????????????,??(???ADA????)????,???????

(????? ???????????? ???????????????) ??????????????:?????

??

??:???????????,??????????,??????????????