??????????????

????:????:????????

?????????????????2025?????????????????????2????????????21??????,???????????????????????«??»????“Base-modified nucleotides mediate immune signaling in bacteria(??)”??????????????????????????????????????????(???)?????????,???????????????“???????”(Kongming),?“????????????????”??????,???????????????????

????,??????,??“???????”???????1950??????(????cAMP?cGMP)??,??????????????????,??????,???????,???????????,?????????KomA(?????????A)?KomB(??????B)?KomC(?C)???????????????,?????????????(DNK)????????????????????“??????”:KomA??????????????????DNK??,?(dAMP)?????????????????dITP???????????KomC??NAD⁺,??????“??”??????????????,??,??“?????”??????????????????,?????????????????“????????????????????????????”????????????,???

??,“?”???????????,?????(???????KomB-KomC????????????KomA)????????????????????????,??????dITP???:????,??????????????????(???ADA????????????????????)??????,???

(???? ???? ??) ?????????????:??