???????:??“????”????

????:????????:?????

???????12???????4??????? 2011??????,?????????????????,??????????,?,????

???,?????????????????,???????,??“?”??????????????????????????,??……

“????????????????”??

1994??????,?????????????????????????,?????????,????,??????????????????????????,???????????????????????GMP?????????????,??????GMP?????????????

??????21??????????,?????????????,?????????????????????,??,??????????

?????????,????????????????????,???????????????????????,?????

??????,?????????????VEGF?????????,2004??????????,????????????????,?????

????????,??????,?????,??????????????????“?”??,???

??????????????????????????????????????????????,???

????????????????????,??????????????,??????????????????????????,??,????????????????????????????

???,??,????????????,?????????????????????,??????????,?????????,????????????????????????????????,????10???????????10?????????????,???????

2014????????????????3??,????????????(????????)?????????????,???????????,?????????????,????????????

2????2016???,???????????????9800????/??????????????????7200????????????/?????

?“?”??

?5????????????,???21.2%,???

??????,????

???????,?????,?????????????????4%,???????????????????,?????????????????????????,????????????“????????????”???

???????????????????????????,??????????????????,??????????????20??11?,16????????????????????????,9????????????

???,???????????????????????

????????????,?????????????????????????????????????????????????????????,???,?,???????????,??,????????????????????????

?????????,??,?????????????,?????????????????????????????????,???????????????????????????,??,?????????????????

???????????

?,?????????,????????????????????

????????????,?????????KH631,??????????????2023???????“??”????????????,????????????,????I????;KH658???,?????????????VEGF???????,?????????????????????????,2024?????????,KH658???????????????????????????«?????????»(Nature)???????,5?????????????2024?ARVO??ASGCT?????????

??,?KH617???????????I????????????????????????????2023??,KH617????,???????????????

???????,????????????????,?????“??????????????????????”?????,??????????????,?????,???????????

??????,?????,2023?????????,??20%???????????????,????????,????????????????1000??????????

????,???????«??????»??????????????,??????

???????,??????????

????,?,????“????????????”??????

???????????:??????