?????1???14???? (?? ????)“?,?,???????????”????????14??????????,“?????????(ADC)?????????????,??????,??????????????????????,?????????????????????”

???????????????????????,??????,????????????????????????????????,???????????,?????????????,“??????”???

?????,???????????????????,???????????,?????????????????:????????????????????????????????????,??,?20%????30%??,???????:?????????“?,????????”??????????????,??????????????,???

?,????????????????????,???????:???,??????????,?????????????????????,?????????????????????????????????,??????,???????????????,??,??????????,?????????????,?????,?????????????????????????????

?????????????,??????????????-2(HER2)????,???????“HER2??????”???????????????“HER2???”??????,??????????HER2????,????????????HER2?????????????????,HER2?????????????????

????????,??????,HER2???????20%???????????????,?????????????,??????????????,ADC?????“HER2?????????HER2??,???ADC????,?????????????????,????????????????HER2?????????,ADC??????,??‘1+1>2’??????????????????????,??????????????????”

HER2??????45%????????????55%????????????????,???HER2???,????????????HER2?????????????????,?????????HER2???????????????????????????:“?????????????HER2??,??????ADC??HER2??HER2???,??,????HER2????????,????????,??????”

????,ADC????????,???,ADC?????;??????

??,?????????2017??????,???????????,?????,???????,?????????????????????????????:“????,?,??????????????”

??,???????????????????,?????????????????????,??????,??,???:??????????????????????????????????????,??????????,??????40???????????????????????B???????????,?????????????????????????????????,????????????:?????????40???????,????????????????,?????(???????????????) ??????????????:??????????????

??

??:???????????,??????????,??????????????