????:2024-12-06 01:22:30 ??:????
????:???????????:??24??????
??12?????5?? ??,???3b???????????????????SURMOUNT-5?topline?????????????????????????????,????????????(tirzepatide)?????(semaglutide)???????????????,??????1.47????????????????
??????,????????????????????????20.2%,???????????????13.7%i???72?????????,??,???5?????????????????????????????,????????????
??????????????????????????????????, ????????,??GIP??????GLP-1???????????????GIP???????????????GLP-1????????????????????????????????????????????(CKD)????(MMO)??????????????,???????(FDA)????????(OSA)???????????????????????????(FDA)?????????(HFpEF)??????????????
?????????????2022????????????????????5???????????????????????13???(FDA)??????????????????,??????????????2????????????????????;2023????11?????????8???????????,FDA????????????(BMI=30kg/m2)???????????????(BMI=27kg/m2)??????
?????????????????GIP(?)????????????????GLP-1(???-1)??????????????????,???????
“??????????,????????????????????????????????,???,”???????????????Leonard C. Glass????????????????????,“??,????,?????????????????????????????????????????,?????????1.47??????????????????FDA????????GIP/GLP-1??????,???????”
???:“??????????????????,???????????,???????????”
?????,???????????????????,???????31.6%???25%,??????????????16.1%????
??SURMOUNT-5??????,????SURMOUNT?????????????????????,?????
????????????SURMOUNT-5???,?????????????????????????
????????????,SURMOUNT-5(NCT05822830) ?????????????????????????????????????3b ???????,??????????(????????????????????????????????????)????????????????????????????,??????????????????????(tirzepatide)???(semaglutide)????????????751?????,?????1:1?,??(10mg?????15mg)??????(1.7mg?????????????????????2.4mg)???????????????72??,??????????????????
i???????????????????????????(treatment-regimen estimand)????????,?????????????????,??(????)?????,????,????????? ?????:???????????????????
????