?? > ???? > ??

???????????????20.2% ????????????13.7%

????:2024-12-06 01:22:30 ??:????

????:???????????:??24??????

??12?????5?? ??,???3b???????????????????SURMOUNT-5?topline?????????????????????????????,????????????(tirzepatide)?????(semaglutide)???????????????,??????1.47????????????????

??????,????????????????????????20.2%,???????????????13.7%i???72?????????,??,???5?????????????????????????????,????????????

??????????????????????????????????, ????????,??GIP??????GLP-1???????????????GIP???????????????GLP-1????????????????????????????????????????????(CKD)????(MMO)??????????????,???????(FDA)????????(OSA)???????????????????????????(FDA)?????????(HFpEF)??????????????

?????????????2022????????????????????5???????????????????????13???(FDA)??????????????????,??????????????2????????????????????;2023????11?????????8???????????,FDA????????????(BMI=30kg/m2)???????????????(BMI=27kg/m2)??????

?????????????????GIP(?)????????????????GLP-1(???-1)??????????????????,???????

“??????????,????????????????????????????????,???,”???????????????Leonard C. Glass????????????????????,“??,????,?????????????????????????????????????????,?????????1.47??????????????????FDA????????GIP/GLP-1??????,???????”

???:“??????????????????,???????????,???????????”

?????,???????????????????,???????31.6%???25%,??????????????16.1%????

??SURMOUNT-5??????,????SURMOUNT?????????????????????,?????

????????????SURMOUNT-5???,?????????????????????????

????????????,SURMOUNT-5(NCT05822830) ?????????????????????????????????????3b ???????,??????????(????????????????????????????????????)????????????????????????????,??????????????????????(tirzepatide)???(semaglutide)????????????751?????,?????1:1?,??(10mg?????15mg)??????(1.7mg?????????????????????2.4mg)???????????????72??,??????????????????

i???????????????????????????(treatment-regimen estimand)????????,?????????????????,??(????)?????,????,????????? ?????:???????????????????

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