????:1??????????:????????

2??????????2023

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4???????

5?2023??????

???????2025????????????2????????????21??????????????????,??????«???????????»??????????????????“Base-modified nucleotides mediate immune signaling in bacteria(???????)”?????????(????)??,?“?????????”(Kongming),???????????“??”?,?????

??,???????,????“??”??1950?????????????(????cAMP?cGMP)?,??????????????????????????????????,????????????,???????????????????????????????????????,??,?KomA(??A)?KomB(?B)?KomC(????????????C)??????,????????????????(DNK)??“?????????”:KomA??????DNK?,???????????(dAMP)??????dITP????????????????KomC????????????????????NAD⁺,????“??????”????????,??????????,???“??????????????????”??????,????“??”??????????????,??????????????????????????????????????

??????????,“????”?????,?????????????????(???????????????????????KomB-KomC?????????????????KomA)????????????????????????????????,????????????????????dITP??:????,??????(??????????ADA??)?????????,????????????

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