???????????????

???????????1???????????????????14????????????? (?????????? ??????)“?,???????,???”???????14???????????,“?????????????????(ADC)????,??????,??????????????????,??”

?,????????????????,??????????????,?????????????,?,“??”????

?????,???????????????????????????????,????,?????????????:???????????????????????,??????,?????????20%???30%??????????????,??:??????????????“????,???”?????????????????,?????????????,??????

????,???????,???:??????,??????????,????????????????????????,???????????????????????????????????,????,????????????????????????????,??,????????,???????????????,??????????????,?????????????????

?????????????,?-2(HER2)????????????,????????????????????“HER2?????????????????”????“HER2??”???????????????????????,??????HER2?,??????????HER2???????,HER2???

????????,?,HER2?????20%??????,??????????,????????????????????????,ADC???????“HER2????????????HER2???????????????,????????????????ADC??,???????????????,????????HER2??????????,ADC??????,?????????‘1+1>2’??,??????????????”

HER2??????45%?????55%???????????,????????????HER2??????????,??????HER2?????????????,???????????HER2???????????:“???????????HER2?????,??ADC???????HER2???HER2??????,?????????????,?HER2????????????,???,???”

???,ADC??????,????,ADC???????????????????????;???????

???????,????????????????????2017???,??,??,??????????,?????????????????????????????????????????:“????????????,??????????????????????,????????????????????”

?????????????????,???????????????,???,???,?,?????????????:?????????????????????????????,???,????40???????????B??????,?????????????????????????,??????????????????:?????????????????????40??????,???????????????????????,???????????(????????) ??????????:????????