?? > ???? > ??

????????????20.2% ???????????????13.7%

????:2024-12-06 01:08:36 ??:????

????:?????????:????????

????????????????12????????????????5??????????????????? ???????????????,????????????3b?????SURMOUNT-5??????????topline????????????????????????????????????????,???????????(tirzepatide)?????????(semaglutide)??????????????,?????????????????1.47????????????????

???,?????20.2%,?????????????????13.7%i???72???,??,?????5????????????,???????????????

???????????????, ?,?????????GIP??????????????????GLP-1???GIP??GLP-1?????????????????????????????(CKD)???????(MMO)?????????????????????????????,???????????(FDA)??(OSA)??????????????????????????????????????(FDA)???????(HFpEF)???

??????2022??????5???????????????????????13??(FDA)?,????????????????????2??????????????;2023???11???????????????????????8??,FDA????????(BMI=30kg/m2)??(BMI=27kg/m2)??

????????????????????????????GIP(????????)??????GLP-1(????????????????????-1)???????????????????????,??????????????????

“???????,???????????,?,”????????Leonard C. Glass????????????,“??????????????,???,??????????????????????????????????????,?1.47?????????????FDA?GIP/GLP-1???????????????????,?????????”

??:“???????????????????????????,??,???????????”

?????????????,???????????????????????,??31.6%???????????25%,????16.1%?????????

???SURMOUNT-5??????,?SURMOUNT???????????????????????,???

????????????????????SURMOUNT-5?????????,?????????????

?????????????,SURMOUNT-5(NCT05822830) ?????????????????????????????????????3b ???????????????,????????????????????????(??????????????????????????)??????,?????????(tirzepatide)???????????????????????(semaglutide)????????????????751?,??????????1:1?????????????,????????????(10mg????????????????????????????????15mg)????(1.7mg?2.4mg)????????????????????????????72???????????????????????????,???

i?????????????????????(treatment-regimen estimand)?????????????,????,????????????(????)???????,???,??????? ????:????

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