??????????????

????:??????:?????????

????2025??2?????????????21?????????????????,?????????????????«????????????»??“Base-modified nucleotides mediate immune signaling in bacteria(????)”????????????????????????????(?????????)????,?“??”(Kongming),???????“??????”????,???

????,?????????????,?“?????????????????????”?????????????1950?(??????????????????cAMP?cGMP)?????,??????????????????????????????,????????????????????????????????????????????,??????????????????,????,???????????KomA(??????A)?KomB(??B)?KomC(??????C)??????????????,??????????(DNK)?“?”:KomA??DNK???????????,??????(dAMP)??????????dITP???????KomC???????????NAD⁺,???????????????????????“??????????????????”????????????????????????,??,?????????????“????”???,??????“???”???,????????

??????????,“??”??????,???????(?????????????????????????????????????KomB-KomC????KomA)?????????,????????????????????dITP?:???,??????????????????(?ADA??)??,?????????????????

(?? ????????? ????) ?????:???