??????????????
??????2025????2????????????21?????????????????,??????????«????»????“Base-modified nucleotides mediate immune signaling in bacteria(????)”?????????????????????????????????(??)????????????????????,???????“?????????”(Kongming),????“?”?????????????????,???
??????,???????????????,?“???????????”???????????????????1950??(?????????????????????cAMP?cGMP)??,???????????????????,????????????????????,?????????????????????,??????,??KomA(??A)?KomB(?????B)?KomC(??C)???????????????????????,?????????(DNK)???????????“???????”:KomA?DNK??,??????(dAMP)????????????????????????????dITP?????KomC??????NAD⁺,????“????????????”???????????????????????????????????????????????????,???????,???“??”????,??????????????????“??????”??????,?????
???,“???”?????????????,????(???????????????????????KomB-KomC??????KomA)???????????????????,???????????dITP????????????????????:?,??(???ADA??????)?,???????????
(?? ?? ??????????) ???:????
??