???????????????

????:??spa???:????

????????1????????????????14????? (?????????? ???????????????)“?,???????,????”?????14???????????,“??(ADC)????,??????,????????,???????”

???????????????,??????????,????????????????????,????,?????,“???”???????

????,??????????????????,?????????,??????:???????????????????????????????????????????????,??,?20%??????????????????????30%????,?????????????:???????“??????,???????????????????”?????,??,?????

????????,?,??????:??????,?????????,?????????,?????????????????????????????,?????????????????,???????,???????????,??,???????????????,??????,????????????????????

??,??-2(HER2)??????????????,??“HER2??????”???????“HER2??????????????”????????????,????????????HER2?,???HER2?????????,HER2????

??,?????,HER2??????20%??????????????????,?????????,????,ADC???????????????“HER2?????????????????????HER2???????????,??ADC?????,??????????,???????????HER2?????????????????,ADC????,?????????????‘1+1>2’??????????,?????????????????????”

HER2????????????????????45%?????????????????55%????????????????,???????????????????????HER2?,??????????HER2????????,?????????????????HER2???????????????????????:“????????????HER2????????,?????????????ADC???????????????????HER2????HER2???????,??,??HER2???????????????????,???????,??”

?,ADC??,???,ADC????????????????????????;??????????????

???,???????????????2017??????????,?????????????,???,??,???????????????????:“?????????????,????????????????,???????????????”

??????????????????????,????????????,??,???,??????,??:????????????????????????????????,????????????????????????????,???????40????????????????B???????????,??????????,???????:?????????????????40???????????,???????????,???????(??????????) ???????????:??????????????????