??????????????

????2025?????????????2?21????,??«?»??“Base-modified nucleotides mediate immune signaling in bacteria(???????????????????????)”???????????????(???????????)??????,??????“????”(Kongming),??“?????”?????????????????????,???

?????,??????????????,???????“??????????????????”????1950?????????(??????????cAMP?cGMP)??,??????,?????????????,?????????,???,????KomA(????A)?KomB(????????????B)?KomC(????C)?????????,?????????(DNK)??????“??”:KomA???DNK????????????????,????(dAMP)???dITP?????????????????????KomC??NAD⁺,???????“??”??????????????????????,??????????????????,???????????“??????????”????,???????“?????????????????”???,???

????,“?”?????????????,?(????KomB-KomC???????????????KomA)????????????????????????????????,?????????????????dITP???????????:?????????????????,??(??????????????????ADA????????????????????????????)??????,??????????????????????????????????????

(???????????????????? ?????? ?) ????????????:??