??????????????

????:????????:????9598????

??2025????2??21??????,??«??????»????????????????????“Base-modified nucleotides mediate immune signaling in bacteria(??)”????????????????????(????????????)????????????????,?????“????”(Kongming),?????????????“??????”????,???

???????????,??????,?“????”???????????????????1950???(????cAMP?cGMP)??????????,??????????????????????????????,??????????????,?????,??,?????????????????KomA(??A)?KomB(?????????????????????????????????????B)?KomC(??????????C)??????????????,??????(DNK)???“???????????”:KomA??????DNK?????????,?(dAMP)???????dITP???KomC?????????????NAD⁺,?????????“????”???????????????????????????????????????,???????,??????“??”??????,????“?????????????”???????????????????,??????????????????

?,“??????”??????,????????????(???????????????????????KomB-KomC??????????????????KomA)??????????????????????,?dITP????????????:??,?????????(?????????????????????ADA?????)????,???????????

(?? ? ???????) ?????:????